A. These Consultants/Specialists assist the Council members with their evaluations and provide expertise in specific areas, such as management, international regulations, or certain scientific specialties. C. Commercial antibody enterprises are not required to follow PHS or USDA guidelines. D. Cages with automatic watering systems, Which of the following significant changes to a protocol could be administratively approved (in principle) by VVC? C. Sterile technique is required for non-survival surgery even though infections are not a concern. Ignore the size of the hot air inlet vent. The Council is divided into North American, European and Pacific Rim Sections. Adoption in other countries and by agricultural and wildlife programs. A change in principal investigator. When animals are used, AAALAC works with institutions and researchers to serve as a bridge between progress and animal well-being. A. D. To search for procedures that may replace the use of animals, reduce the number of animals used, or refine the methodology to minimize animal pain or distress. Complete the following nuclear equations. C. To provide a narrative justifying the use of the animal model based on experimental data. C. Conduct a quick pilot study to be sure the change is useful. What potential problem(s) should you be aware of when mice are undergoing surgical procedures? Rodents are susceptible to subclinical infections after surgery. You can help Wikipedia by expanding it. A. Unsourced material may be challenged and removed. The Association for Assessment and Accreditation of Laboratory Animal Care International, or AAALAC, is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. A new AAALAC service, begun in 1997 and called the Program Status Evaluation, has taken AAALAC representatives to additional countries, where institutions are striving to understand Which activity would place a study in pain category B? B. Nonaseptic technique for survival surgery in mice is permitted by the Guide for the Care and Use of Laboratory Animals. Changes in animal ownership and movement of animals between facilities during the postoperative period. Which of the following statements is true regarding research antibody production? 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AAALAC International was founded in 1966 and is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. General or regional anesthesia is required to prevent pain. If an animal undergoes non-survival surgery, no preparation of the surgical site is necessary because infections are not a concern. A. A hot-air balloon must be designed to support a basket, cords, and one person for a total weight of $1300 \mathrm{~N}$. Participation as a Member Organization demonstrates commitment to the responsible and humane use of animals in science. B. a) A client with amyotrophic lateral sclerosis (ALS) tells the nurse, "Sometimes I feel so frustrated. Which of the following would NOT be accepted by an IACUC as the sole justification for performing multiple major survival surgeries? According to the AVMA Guidelines for the Euthanasia of Animals, which statement is TRUE for the use of CO2 as a euthanasia agent of mice? AAALAC International accreditation is recognized around the world as a symbol of high quality animal care and use for research, teaching and testing, as well as promoting animal welfare. Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? D. Animals should only be used in human clinical areas during weekday work hours. A practicing scientist with experience in animal research, person who is not a scientist, person who is not affiliated with the organization, and public relations specialist. C. A change in the specific objectives for the project Check all that apply. (This is also called an exclusive or.). In this diverse landscape, AAALAC International uses performance standards to assure harmonization of accredited animal care and use programs globally. Home Flashcards Lab Animal- random IACUC & Short Course questions. Mouse urine and pelt proteins are an allergic hazard to people. AAALAC International is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Institutional Animal Control and Use Committee C. Health problems in an animal B. Which organization is responsible for monitoring Also, for long-term anesthesia there is an increased risk of pain due to recovery of pain sensation between repeated doses. To conduct voluntary evaluations of institutional animal care and use programs. The IACUC can exempt an animal for scientific reasons. C. A public relations specialist, veterinarian, practicing scientist with experience in animal research, and person who is not a scientist. Which of the following activities WOULD place an animal in category E? If you have questions in advance of the webinar, please send them to olawdpe@mail.nih.gov. AAALAC International is a private, nonprofit organization that promotes the humane Typically, subcutaneous injections in mice: Which type of bedding is recommended for use in postoperative housing for mice? A. AAALAC International 301.696.9626 | www.aaalac.org Booth: 8 AAALAC International promotes the humane treatment of animals in science, research, and education through voluntary assessment . The Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (the Ag Guide). Which of the following statements about postoperative care records is false? Minor changes to a protocol (such as changes in personnel [other than principal investigator], laboratory location, or change in title) do not require formal IACUC review and approval. The European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, Council of Europe (ETS 123). E. Death from CO2 can be verified solely by a lack of respiration (apnea). But like others in the animal welfare arena, AAALAC endorses the use of animals to advance medicine and science when there are no non-animal alternatives, and when it is done in an ethical and humane way. The Animal Welfare Regulations require the IACUC to do what two things regarding alternatives? The USDA requires documentation of all postoperative care and retention of records for one year after the death of the animal. Which of the following activities would place an animal in category E? A. D. Dogs must be provided additional exercise regardless of the floor area of the cage. Once a report of mistreatment, misuse, or noncompliance is received, the AWR and PHS Policy require the IACUC to review and investigate the allegations (if warranted). With great appre ciation to rese archers, IACUC members, veterinarians, EH&S and IACUC specialists, we announce that AAALAC has finalized their review of UCSFs animal care and AAALAC International promotes the responsible treatment of animals in science through a voluntary accreditation program. All of the following are mouse strains except: A research mouse will typically consume how much food a day? What document provides the guidelines for working with infectious diseases in animal research? While restraining a mouse, a technician should check for which of the following? Members of the Council are chosen to serve based on their extensive experience in the fields of veterinary medicine, laboratory animal science or animal research, and their commitment to humane animal care and use. These "Member Organizations" include the American Heart Association, American Veterinary Medical Association, Asian Federation of Laboratory Animal Science Associations, European Society of Laboratory Animal Veterinarians, the National Association for Biomedical Research, and the Society of Toxicology. The Guide for the Care and Use of Laboratory Animals (the Guide, NRC 2011); The Guide for the Care and Use of Agricultural Animals in Research and Teaching (the Ag Guide, FASS 2010); and. The requirement for exercise depends upon housing space provided to the animal and the number of animals occupying that space. The fur should Accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International has long been trumpeted as being the "gold standard" Which of the following is NOT a reason to provide environmental enrichment? Surgery that penetrates and exposes a body cavity or produces substantial physical impairment is defined as what kind of surgery? Julie S Snyder, Linda Lilley, Shelly Collins, Explain the important distinctions between **periods and groups of the periodic table**. A. B. The Association for Assessment and Accreditation of Laboratory Animal Care International, or AAALAC, is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Why should an IP injection be made on the mouse's right side? Scientific reasons B. B. A. B. D. A veterinarian, practicing scientist with experience in animal research, person who is not a scientist, and person who is not affiliated with the organization. C. The attending veterinarian cannot exempt an animal, even for medical reasons. The Columbia University animal care and use program is proud to be accredited by AAALAC International, who will be conducting a triennial site visit of Columbia Assist with writing the basic science portions of a grant application. Which organization is responsible for monitoring institutional compliance with PHS Policy? Which of the following represents good practice in oral gavage of mice? Office of Laboratory Animal Welfare (OLAW) Which is a characteristic of microchips used to identify mice? The Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. The needle tip should be inserted behind the incisors. What is a primary mission of the Animal Welfare Information Center (AWIC), a part of USDA? D. Written postoperative care records are not necessary, as long as proper care is provided and treatments are administered. B Investigators who observe animals that appear to be in immediate danger or pain should first take steps to remove the animal from the threat and contact the attending veterinarian or IACUC. However, agricultural animals used in biomedical research may need to be housed according to the Guide while on study. C. Sponsors a voluntary accreditation program for animal care and use programs. A. Ferrets and cats Using appropriate personal protective equipment can reduce the risk of allergies to mouse urine and pelt proteins. Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? A. Animal density in the euthanasia chamber is not a concern. These consultants assist the Council members with their evaluations and provide expertise in specific areas, such as management, international regulations, or certain scientific specialties. 20 workers can build a wall in 30 days, how many days will 15 workers take to build the same wall. C. The veterinarian cannot exempt an animal, even for medical reasons. Locked bedroom doors are a common sight in many homes. Thermal support is required by USDA regulations. Which entity is generally given institutional responsibility for deciding if an individual investigator is properly trained and qualified to perform animal procedures? Lets start with the sandy beaches, warm water, and fantastic weather. Which of the following is true about mice in the age range of 1-5 days? Daily observations are usually recorded during the postoperative period. Shock due to low blood volume and anemia. Nonverbal communication is defined as how people communicate with each other without talking or writing. The Animal Welfare Regulations (AWR) do not currently apply to which of the following animals? The IACUC must be notified of the need for more animals to achieve statistical significance. A In general, neonates are resistant to low oxygen levels (hypoxia), and accordingly carbon dioxide is not very effective as a euthanasia agent unless there is prolonged exposure. What is generally a superior anesthesia choice for mice undergoing major surgical procedures? Describe the fluid-mosaic model of membrane structure. Major survival surgery on non-rodent mammals C A mandated IACUC function is to conduct reviews of the animal care and use program on a semiannual basis. In the years that followed, AAALAC accredited hundreds of organizations across the United States, raising the benchmark for laboratory animal care to new heights. which of the following is true of aaalac international? Bath and body works visor clip instructions, What time does the next fortnite season come out, All inclusive miami vacation packages with airfare, How to remove recent inquiries from credit report, How much is 2.5 liters of water in gallons. Which of the following protocol changes require IACUC approval? C. Mice will continue to groom themselves, even when in pain or distress. A. What is the genus and species name of the mouse used in research? D An effective IACUC protects both the investigator and organization, while inspiring confidence amongst the general public that animal activities are being performed in an ethical manner. The use of a new blood collection technique that causes less pain and distress. Lethal dose experiments in which animals are allowed to die without intervention. B. Retroorbital blood collection from a mouse performed under anesthesia. Which of the following can provide valuable information in assessing pain and distress in mice? D. Convenience of the research and husbandry staff, According to the Guide, which housing is recommended preferentially for domesticated rodents? D A proper search for alternatives to procedures that cause more than momentary pain or distress includes using database(s) appropriate for the field of study (e.g., Medline), listing the period covered by the search, the date the search was conducted, and providing a list of relevant keywords to indicate that an alternative to the painful or distressful procedure was sought. A mouse with a moderately painful condition may appear and behave normally. C. Mice lose body heat rapidly under anesthesia. B. Which of the statements concerning blood collection in mice and rats is TRUE? C. Those organizations that accept U.S. Department of Agriculture (USDA) research funds. D. A goal of sterile technique is to prevent contamination of the surgical site. A. Compared to adults, neonates are much more susceptible to low oxygen levels, and quickly succumb to death by carbon dioxide inhalation. B. Anesthetize or sedate animals to reduce the chances of accidental human needle sticks. The Board appoints AAALACs Council on Accreditation, the group responsible for evaluating animal programs and determining their accreditation status. Therefore, it is unnecessary to remove fetuses for euthanasia after the dam is euthanized (AVMA Guidelines 2013). C. Gas anesthesia (using a vaporizer) is generally optimal for providing extended anesthesia. The correct dental formula of the mouse is: Which statement about the Occupational Health and Safety Program is false? The Council also appoints a roster of ad hoc consultants. B. D. Supportive care and monitoring can be discontinued when the mice have recovered from anesthesia. Those organizations that sell vertebrate animals for research, teaching, or testing. A veterinarian, practicing scientist with experience in animal research, person who is not a scientist, and person who is not affiliated with the organization. For example, when we wink at someone, offer a strong handshake or back away, we are Pheochromocytomas are catecholamine-secreting neuroendocrine tumors. Investigators must participate in all aspects of the Occupational Health and Safety Program, including immunizations. Major survival surgery on rodents, non-survival surgery, and major non-survival surgery on non-rodent mammals do not require such a dedicated suite. C. Studies in which animals experiencing pain are allowed to die without pain relief. Which of the following sets of IACUC members are required by the AWA and/or PHS? Lift some skin on the back of the mouse, and insert the needle into the base of the tent. Let us have a look at your work and suggest how to improve it! Creates additional regulations and guidelines that govern animal use. (1) If, in the opinion of the attending veterinarian, it is inappropriate for certain dogs to exercise because of their health, condition, or well-being, the dealer, exhibitor, or research facility may be exempted from meeting the requirements of this section for those dogs(2) A research facility may be exempted from the requirements of this section if the principal investigator determines for scientific reasons set forth in the research proposal that it is inappropriate for certain dogs to exercise." For research on animal subjects, at what point must an investigator receive IACUC approval for the proposed animal activities and procedures? B. Fell free get in touch with us via phone or send us a message. Institutional Animal Care and Use Committee C. The IACUC has regulatory authority to stop any animal activities to protect either animals or people. Which of the following statements is TRUE about blood collection in mice? The Council conducts on-site visits and extensive evaluations, and provides ongoing advice to help organizations achieve and maintain accreditation. D Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. AAALAC International. All of the following are practical methods of identifying mice EXCEPT: When producing monoclonal antibodies in vivo, what parameter should be considered? Currently nearly 900 companies, universities, hospitals, government agencies and other research institutions in 40+ countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. Rodent fetuses along with other mammals are unconscious in utero, and hypoxia does not evoke a response. Driving in the summer, winter, or rainy season may be to blame for the unpleasant odor inside the car. Extreme weather, dust, Usually a situation suddenly arises in your life where you have an urgent need to copy text messages off your iPhone.When you do a Google search for saving iPhone text messages to computer, there is Fortnite Chapter 4 is nearly here, presumed to be launching just days from now, so its time to look ahead to whats next. Weve got your back. Studies that require gastric emptying may still require pre-surgical fasting. B. When does accreditation by AAALAC International provide you with an exemption from some of the mandates of the Guide for the Care and Use of Laboratory Animals? The skin should be disinfected around the incision site. IACUCs are not mandated to write the basic science portions of grant applications or animal use protocols for investigators. Injectable agent doses vary by species and individual variability makes repeat dosing difficult. Pioneers cut bricks from sod-basically, prairie soil as a matrix, and grass and its root system as reinforcement. C. Typical services include rabies immunizations, tuberculosis testing, and tetanus immunizations. D. Shock due to excessive blood volume, and hypercholesterolemia. A. UsingAAVrh10,Raetal.achievedgreaterefcacyin mice by either increasing the dose via combined route of administration,27 combination of systemic AAVrh10 with . A. C Gas anesthesia offers maximal control over depth, duration, and recovery period and should be used whenever possible. D. The Office of Laboratory Animal Welfare (OLAW). Female mice have how many pairs of nipples? C. Dogs and cats Which of the following is true of AAALAC International? D. 5 percent, Because they cannot vomit and are not prone to aspiration pneumonia, which of the following animals should not routinely be fasted prior to surgery? Which of the following is not a good justification for housing animals individually? It is designed to provide general legal information and is not a substitute for legal advice provided by an attorney who is a member of One traditional framework that has been used to express the channel mechanism is the concept of flow. A. D. Laboratory use of recombinant chemical agents for in vitro work. B. Which statement is true regarding venipuncture procedures in mice: Which of the following methods is considered acceptable for euthanizing mice? More than 1,000 companies, universities, hospitals, government agencies and other research institutions in 47 countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. In this way, AAALAC International is where science and responsible animal care connect. This is done through AAALAC's voluntary A dedicated surgery suite must be used for which surgery? As AAALAC's accreditation program has grown to encompass many wildlife and agricultural animal research programs, dropping the use of the word "laboratory" in conjunction with AAALAC allows for greater inclusivity. D. The selection of an appropriate euthanasia method should address considerations of humaneness to the animal, safety for the staff and onlookers, and experimental needs. Which of the following is an example of refinement per the three Rs of Russell and Burch? Do you Cars lack adequate air circulation since they are enclosed places. To supplement the nutritional deficiencies of standard animal chow, Environmental enrichment should be applied consistently to all animals that are part of a study. Which of the factors below affect the routine sanitation schedule in animal facilities? Contracting with a commercial enterprise to produce custom antibodies requires IACUC approval. Which of the following statements is TRUE about pain in rodents? Some use accreditation as a symbol of qualityit shows that an institution is serious about setting, achieving and maintaining high standards for animal research programs. Which of the following falls within the range of the total blood volume of adult mice? Conduct reviews of the animal care and use program on a semiannual basis, Institutional Animal Care and Use Committee. The exercise must take place outside the building. AAALAC accreditation also promotes scientific validitywhen research involves animals, reliable results depend on healthy animals and superior animal care. Which of the following statements about the postoperative period is FALSE? AAALAC International is a private, nonprofit organization that promotes humane treatment of animals in science through a voluntary international accreditation program. Which measure can correct respiratory depression in anesthetized mice? B. Humane methods of animal experimentation Biosafety in Microbiological and Biomedical Laboratories, Recombinant DNA inserted into the genome of transgenic mice may NOT be covered by the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules. D. Surgery performed under anesthesia. C. Applicable federal mandates require the use of aseptic technique for survival surgery in mice. D. Mice displaying normal behavior can be assumed to be free of pain and distress. If the investigator believes the event is due to misuse, mistreatment, or noncompliance, the details of the incident should be reported to the IACUC (or use another reporting method recommended by their organization), so that the incident can be reviewed and investigated (if warranted). What does "IACUC" stand for? The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following types of experiments? To conduct voluntary evaluations of institutional animal care and use programs. It provides a mechanism for peer evaluation of animal care and use programs B. Remove the animal from the threat if safe to do so and contact the attending veterinarian or IACUC. Which statement is true about the anogenital distance in mice? I went through the test 5 times and encountered these 63 questions on November 29th, 2018. A. Spontaneous vocalization is rarely observed hunched posture, inactivity, and decreased appetite all indicate distress in mice. The balloon material has a mass of $60 \mathrm{~g} / \mathrm{m}^2$. Which statement is true regarding care procedures for mice undergoing surgery? A. Accredited Which task is NOT a function of the IACUC? A. Which of the following statements about identifying mice is NOT true? The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following types of experiments? Which of the following is a mandated IACUC activity? B. Inoculation of nonrecombinant infectious agents into animals The Guide to Proper Procedures in Research Facilities To provide assistance with alternatives and database searches. A protocol submitted to the IACUC should demonstrate a clear hypothesis driven thought process and a thorough understanding of the number, species, housing and transport requirements of animals proposed for use in research studies. A. A. Neonatal mice are more susceptible to the effects of carbon dioxide and typically succumb to CO2 more rapidly than adult mice. D. Retro-orbital is a preferred route for blood collection because of animal welfare considerations. a. By the end of the experiments Techniques for creating transgenic animals All answers are correct. D. Applicable federal mandates require identical practice standards for the conduct of aseptic surgery in mice and nonrodent mammals. AAALAC International standards for accreditation are set forth by the Guide for the Care and Use of Laboratory Animals, established by the U.S. National Research Council in 2011. C. A change in personnel. B. D. Major. B According to the AWR (3.81.d. Write an expression using boolean variables a and b that evaluates to true when only one of a and b is true, and that is false if a and b are both false or both true. D. Rodents and rabbits. In this edition, we will bring you up to speed on AO VET activities over the past five months. Both OLAW and AAALAC require oversight of all vertebrate animal species. D. Those organizations that accept Public Health Service (PHS) or National Science Foundation (NSF) funding. Collecting tail snips from adult rodents for genotyping under local or general anesthesia. The investigator A. The standards in the Guide go above and beyond what is required by law. In 1996, AAALAC changed its name to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). D The federally mandated search for alternatives helps to fulfill the requirement set forth in the AWA policies to consider alternatives to procedures that may cause more than momentary pain or distress. B. Which types of animals must have access to environmental enrichment, as mandated by the Animal Welfare Regulations? D. Each organization must offer an Occupational Health and Safety Program for personnel who have significant contact with laboratory animals. C. No adequate treatment is available should an animal become exposed. Restraint can be used as a normal component of animal housing, Restraint for brief periods of time during experimental procedures do not need to be mentioned in the animal use protocol. B The "Animal Welfare Act" of 1966 is enforced by the USDA and was enacted to regulate the sale of pets to research facilities, and as such, do not regulate mice, rats (or birds), bred for use in research. C. Intervention must occur to remove an animal from a study, sometimes by euthanizing the animal. The mandibular vein, lateral saphenous vein, and retro-orbital sinus are acceptable survival sampling sites. Today, nearly 1,000 organizations worldwide (as of 31 December 2017) are accredited by AAALAC International. Some of the institutions that have earned AAALAC accreditation include the Sloan-Kettering Cancer Center, St. Jude Children's Research Hospital, The American Red Cross, and the National Institutes of Health. What diameter spherical balloon will just support the total weight? Which Public Health Service (PHS) organization is responsible for monitoring organizational compliance with PHS Policy? Daily observations are usually recorded during the postoperative period, and these written records should be maintained for at least a year after the death of an animal. B. Mice are such small animals that the risk of vomit gaining entry into the trachea and causing pneumonia is very small.
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